Simultaneous Spectrophotometric Estimation of Rabeprazole Sodium and Domperidone Maleate in their Combined Pharmaceutical

Two simple, rapid, economical, specific, precise and accurate spectrophotometric methods have been developed for simultaneous estimation of rabeprazole sodium and domperidone maleate in their combined pharmaceutical dosage forms. Rabeprazole sodium and domperidone shows absorption maxima at 285 nm and 287 nm respectively. The first method is based on the simultaneous equations. In the simultaneous equations, the signals were measured at 285 nm and 287 nm and concentration of each drug was obtained by using the molar absorptivity values calculated for both the drugs at 285 nm and 287 nm. Second method involves analysis of drug by multicmponent mode of the instrument. Both the drugs obeyed beer’s law in the concentration ranges of 2 – 30 mg/ml employed for these methods. The results of analysis were validated statistically and by recovery studies. Both of these developed methods were found to be simple, precise and accurate and can be utilize as a quality control tool for the simultaneous estimation of both drugs from their combined marketed formulation.